GIPR/GLP-1R/GCGR Retatrutide 100% Safe and Fast Delivery to USA Custom Manufacturing CAS NO.2381089-83-2 CAS NO.2381089-83-2

Retatrutide             NO1 Supplier in China

Quick Details

• ProName: High purity and low price Retatrutide ...
• CasNo: 2381089-83-2
• Molecular Formula: C221H342N46O68
• Appearance: White powder
• Application: cosmetic research
• DeliveryTime: Arrange for dispatch within 1-2 days a...
• PackAge: According to customer order quantity a...
• Port: Shenzhen
• ProductionCapacity: 500 Kilogram/Day
• Purity: 99%
• Storage: Store in a dry, cool and ventilated pl...
• Transportation: FedEx, USPS, UPS, etc. If customers ha...
• LimitNum: 1 Milligram
• Moisture Content: 0.01
• Impurity: 0.01
• Industrial grade: 99
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• Lose 37 pounds in 6 months! Retatrutide opens the era of "tri-receptor agonists" for weight loss NEJM publishes the latest research

Introduction: Recently, the latest phase 2 study data of the "tri-receptor agonist" Retatrutide for obesity treatment was published in the New England Journal of Medicine (NEJM, IF: 158.5). The study showed that: taking the drug once a week, at 24 weeks, the average weight loss of overweight/obese non-diabetic subjects in the Retatrutide 12mg group reached 18.7 kg (17.5%); in the secondary endpoint, the average weight loss of the Retatrutide 12mg group at the end of 48 weeks of treatment reached 26.2 kg (24.2%).

Retatrutide: Opening the era of "triple receptor agonist" for weight loss
Retatrutide is a triple agonist peptide for glucagon receptor (GCGR), glucose-dependent insulinotropic polypeptide receptor (GIPR) and glucagon-like peptide-1 receptor (GLP-1R). Retatrutide has a half-life of about 6 days and is administered once a week.
Compared with endogenous receptor ligands, Retatrutide has weaker effects on human GCG receptors and GLP-1 receptors (0.3 and 0.4 times, respectively), but stronger effects on human GIP receptors (8.9 times).
In 6 months, the average weight loss was 18.7 kg!
This Phase 2 study is a 48-week randomized, double-blind, placebo-controlled trial designed to evaluate the efficacy, tolerability and safety of Retatrutide at different doses and dose escalation regimens in overweight/obese non-type 2 diabetic subjects with weight-related comorbidities.
The study was conducted in the United States and included a total of 338 subjects. The subjects were randomly assigned in a ratio of 2:1:1:1:1:2:2 to receive Retatrutide 1 mg, 4 mg (initial dose of 2 mg), 4 mg (initial dose of 4 mg), 8 mg (initial dose of 2 mg), 8 mg (initial dose of 4 mg), 12 mg (initial dose of 2 mg) or placebo once a week by subcutaneous injection for 48 weeks. The primary endpoint was the percentage change in weight compared with baseline at week 24; secondary endpoints included the percentage of weight change from baseline to week 48 (weight loss ≥5%, ≥10% or ≥15%) and drug safety.
The results showed:
At 24 weeks, the average weight loss in the Retatrutide 12mg group was 18.7 kg (17.5%), the average weight loss in the 1mg group was 7.2%, the average weight loss in the 4mg group was 12.9%, and the average weight loss in the 8mg group was 17.3%. In contrast, the average weight loss in the placebo group was only 1.6%.
At 48 weeks, the average weight loss in the Retatrutide 12mg group was 26.2 kg (24.2%), the average weight loss in the 1mg group was 8.7%, the average weight loss in the 4mg group was 17.1%, and the average weight loss in the 8mg group was 22.8%. In contrast, the average weight loss in the placebo group was only 2.1%.

Figure 1 Changes in weight in the Retatrutide group
More than 60% of patients lost ≥10% of their weight!
The results showed that the proportion of patients who achieved the weight loss target (≥5%, ≥10% and ≥15%) at 48 weeks was: 92%, 75% and 60% in the Retatrutide 4 mg group; 100%, 91% and 75% in the Retatrutide 8 mg group; and 100%, 93% and 83% in the Retatrutide 12 mg group. In comparison, the placebo group was 27%, 9% and 2% respectively.
The drug safety is good, mainly "gastrointestinal adverse reactions"
In terms of drug safety, the most common adverse events in the Retatrutide group were gastrointestinal-related events, which were dose-related, mostly mild to moderate, and the starting dose (2mg vs. 4mg) group was relatively mild. The adverse reaction of "increased heart rate" was also dose-dependent, reaching a peak at 24 weeks and then gradually declining.
Table 1 Adverse reaction events

In this phase 2 trial, subjects treated with once-weekly retatrutide achieved significant weight loss at 24 and 48 weeks in a dose-dependent manner. The results of this study lay a solid foundation for the Phase 3 trial, and the effectiveness and safety of Retatrutide in treating obesity will be further explored in the future.

Superiority

 Advantages

1、 the purity of all products >99%.

2、 high quality products and competitive prices.

3、 Sufficient inventory, fast delivery, and the ability to meet customer needs.

4、 safe and prudent shipping a variety of transportation modes for you to choose.

5、 Delivery time within 7 days after payment and 24 hours of quality after-sales service 

FAQ

Q1. How does your factory control quality
A:All the raw material purchasing and production quality control are strictly following the ISO9001: 2008 management system. Besides, the full-featured detection equipment and GMP quality management system to provide the strongest guarantee for high quality product. We can provide our customers the detailed test report for the quality evaluation before the sample.

Q2. What's your main markets
A:North America, Europe, Asia, etc.

Q3. What is your delivery term and delivery period
A:We accept FOB, CIF, etc. You can choose the one which is the most convenient or cost effective for you. The sample within 3 days, and bulk order within 5 days.

Q4. What is your package
A:Powder: PE bag, glass bottle or PTFE bottle for inner packing, and aluminium foil bag for outer packing.
Liquid: glass bottle or PTFE bottle for inner packing, and aluminium foil bag for outer packing.
Bulk order: Fiber drum or steel drum.

Q5. What is the payment term
A:Normally we advise customers use Trade Assurance(is a free payment protection service for buyers is offered by Alibaba group), and we also receive T/T, .

Q6. Will you supply samples for test the quality
A:We'd like to offer our customers the free samples for the quality evaluation for most products, but the shipping cost is borne by customers.